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Germline polymorphisms and alternative splicing of human immunoglobulin light chain genes

29 Sept 2021

Abstract excerpt

Inference of germline polymorphisms in immunoglobulin genes from B cell receptor repertoires is complicated by somatic hypermutations, sequencing/PCR errors, and by varying length of reference alleles. The light chain inference is particularly challenging owing to large gene duplications and absence of D genes. We analyzed the light chain cDNA sequences from naïve B cell receptor repertoires from 100 individuals....

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PMID: 34693229
DOI: 10.1016/j.isci.2021.103192

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