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Altered cfDNA fragmentation profile in hypomethylated regions as diagnostic markers in breast cancer

22 Sept 2023

Abstract excerpt

BACKGROUND: Breast cancer, the most common malignancy in women worldwide, has been proven to have both altered plasma cell-free DNA (cfDNA) methylation and fragmentation profiles. Nevertheless, simultaneously detecting both of them for breast cancer diagnosis has never been reported. Moreover, although fragmentation pattern of cfDNA is determined by nuclease digestion of chromatin, structure of which may be...

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PMID: 37740218
DOI: 10.1186/s13072-023-00508-4

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