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Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington’s disease

30 Jun 2022

Abstract excerpt

Huntington's disease (HD) is an inherited neurodegenerative disease caused by expansion of cytosine-adenine-guanine (CAG) repeats in the huntingtin gene, which leads to neuronal loss and decline in cognitive and motor function. Increasing evidence suggests that blood-brain barrier (BBB) dysfunction may contribute to progression of the disease. Studies in animal models, in vitro models, and post-mortem tissue find...

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PMID: 35773691
DOI: 10.1186/s12987-022-00347-7

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