Article

Identification of functional rare coding variants in IGF-1 gene in humans with exceptional longevity

2024-10-13

Abstract excerpt

Diminished signaling via insulin/insulin-like growth factor-1 (IGF-1) axis is associated with longevity in different model organisms. IGF-1 gene is highly conserved across species, with only few evolutionary changes identified in it. Despite its potential role in regulating life span, no coding variants in IGF-1 have been reported in human longevity cohorts to date. This study investigated the whole exome sequenci...

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Literature Corpus work: 20dc197f-6716-5ee9-93c6-585a6622a871
DOI: 10.1101/2024.10.11.617885

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