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Article

Disorders of IGFs and IGF-1R signaling pathways.

Molecular and cellular endocrinology - 1 Dec 2020

Forbes Briony E, Blyth Andrew J, Wit Jan M

Abstract excerpt

The insulin-like growth factor (IGF) system comprises two ligands, IGF-I and IGF-II, that regulate multiple physiological processes, including mammalian development, metabolism and growth, through the type 1 IGF receptor (IGF-1R). The growth hormone (GH)-IGF-I axis is the major regulator of longitudinal growth. IGF-II is expressed in many tissues, notably the placenta, to regulate human pre- and post-natal growth...

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Identifiers

PMID: 32941924
DOI: 10.1016/j.mce.2020.111035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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