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Detection rate of IGF-1 variants and their implication to protein binding: study of over 240,000 patients

9 Oct 2023

Abstract excerpt

OBJECTIVES: To determine the detection rate of IGF-1 variants in a clinical population and assess their implications. METHODS: IGF-1 variants were detected based on their predicted mass-to-charge ratios. Most variants were distinguished by their isotopic distribution and relative retention times. A67T and A70T were distinguished with MS/MS. Patient specimens with a detected variant were de-identified for DNA...

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PMID: 37811857
DOI: 10.1515/cclm-2023-0709

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