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Article

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors.

Nature cell biology - 1 May 2015

Cebola Inês, Rodríguez-Seguí Santiago A, Cho Candy H-H, Bessa José, Rovira Meritxell, Luengo Mario, Chhatriwala Mariya, Berry Andrew, Ponsa-Cobas Joan, Maestro Miguel Angel, Jennings Rachel E, Pasquali Lorenzo, Morán Ignasi, Castro Natalia, Hanley Neil A, Gomez-Skarmeta Jose Luis, Vallier Ludovic, Ferrer Jorge

Abstract excerpt

The genomic regulatory programmes that underlie human organogenesis are poorly understood. Pancreas development, in particular, has pivotal implications for pancreatic regeneration, cancer and diabetes. We have now characterized the regulatory landscape of embryonic multipotent progenitor cells that give rise to all pancreatic epithelial lineages. Using human embryonic pancreas and embryonic-stem-cell-derived...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25915126
DOI: 10.1038/ncb3160
PMCID: PMC4434585

Genes

TEAD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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