Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2014

Kuchibhotla Kishore V, Wegmann Susanne, Kopeikina Katherine J, Hawkes Jonathan, Rudinskiy Nikita, Andermann Mark L, Spires-Jones Tara L, Bacskai Brian J, Hyman Bradley T

Abstract excerpt

Alzheimer's disease (AD) is pathologically characterized by the deposition of extracellular amyloid-β plaques and intracellular aggregation of tau protein in neurofibrillary tangles (NFTs) (1, 2). Progression of NFT pathology is closely correlated with both increased neurodegeneration and cognitive decline in AD (3) and other tauopathies, such as frontotemporal dementia (4, 5). The assumption that mislocalization...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dependovirus
Share to Image Processing, Computer-Assisted

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Neurological

Share to Neurofibrillary Tangles

Share to Photons

Share to tau Proteins

Share to Tauopathies

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 24368848
DOI: 10.1073/pnas.1318807111
PMCID: PMC3890777

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo.PMID 24368848Read ↗

Functional connectivity favors aberrant visual network c-Fos expression accompanied by cortical synapse loss in a mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

Spatial coding defects of hippocampal neural ensemble calcium activities in the 3xTg-AD Alzheimer’s disease mouse modelSemantic proximity Read ↗

Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer's disease mouse modelSemantic proximity Read ↗

Humanized tau and amyloid-β deposition accelerate tau propagation, neuronal cell loss and neurophysiological dysfunction in novel mouse models of primary age-related tauopathy and Alzheimer’s diseaseSemantic proximity Read ↗

Aberrant miR-339-5p/neuronatin signaling causes prodromal neuronal calcium dyshomeostasis in mutant presenilin miceSemantic proximity Read ↗

Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice.Semantic proximity Read ↗

The amyloid precursor family of proteins in excitatory neurons are essential for regulating cortico-hippocampal circuit dynamics in vivoSemantic proximity Read ↗

Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses.Semantic proximity Read ↗

Synaptic Loss in Alzheimer's Disease: Mechanistic Insights Provided by Two-Photon in vivo Imaging of Transgenic Mouse ModelsSemantic proximity Read ↗

Impaired Cholinergic Excitation of Prefrontal Attention Circuitry in the TgCRND8 Model of Alzheimer's Disease.Semantic proximity Read ↗

Compartment-specific analysis reveals disrupted astrocytic calcium transients in Alzheimer's miceSemantic proximity Read ↗

Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.