Article

Pharmacological activation of PIEZO1 in human red blood cells prevents <i>Plasmodium falciparum</i> invasion

2021-05-28

Abstract excerpt

An inherited gain-of–function variant (E756 del) in the mechanosensitive cationic channel PIEZO1 was recently shown to confer a significant protection against severe malaria. Here, we demonstrate in vitro that human red blood cell (RBC) infection by Plasmodium falciparum is prevented by the pharmacological activation of PIEZO1. The PIEZO1 activator Yoda1 inhibits RBC invasion, without affecting parasite intraer...

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Literature Corpus work: 63d5914d-61d0-5ec5-b8ac-967fc0cf3da9
DOI: 10.1101/2021.05.28.446171

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