Article

PIEZO1-dependent erythrocyte dehydration as the mechanism for selection of an allele protecting from severe malaria

2022-04-01

Abstract excerpt

PIEZO1 is a cation specific mechanoreceptor channel implicated in red blood cell (RBC) volume homeostasis. Several PIEZO1 gain of function (GoF) variants demonstrate delayed channel inactivation and can cause hereditary xerocytosis (HX), a disease characterized by hemolytic anemia, RBC dehydration, and shape distortion. The milder PIEZO1 E756del GoF variant, prevalent in populations of African descent, protects c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b9ae535e-d320-5c10-9920-a9dedabfc88a
DOI: 10.1101/2022.03.31.486604

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PIEZO1-dependent erythrocyte dehydration as the mechanism for selection of an allele protecting from severe malariaDOI 10.1101/2022.03.31.486604Read

Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection.Semantic proximity Read

Pharmacological activation of PIEZO1 in human red blood cells prevents <i>Plasmodium falciparum</i> invasionSemantic proximity Read

Common Piezo1 allele in African populations causes xerocytosis and attenuates Plasmodium infectionSemantic proximity Read

Piezo1 links mechanical forces to red blood cell volume.Semantic proximity Read

Proteome alterations in erythrocytes with PIEZO1 gain-of-function mutations.Semantic proximity Read

A common polymorphism in the mechanosensitive ion channel PIEZO1 is associated with protection from severe malaria in humansSemantic proximity Read

Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1.Semantic proximity Read

A common polymorphism in the druggable ion channel <i>PIEZO1</i> is associated with protection from severe malariaSemantic proximity Read

Disorders of erythrocyte hydrationSemantic proximity Read

Recent advances in the pathophysiology of PIEZO1 ‐related hereditary xerocytosisSemantic proximity Read

Disorders of red cell volume regulationSemantic proximity Read

Otenabant is a Selective Antagonist of Human PIEZO1Semantic proximity Read