Article

Deciphering the RNA recognition by Musashi-1 to design protein and RNA mutants for in vitro and in vivo applications

2024-10-29

Abstract excerpt

RNA Recognition Motifs (RRMs) are essential post-transcriptional regulators of gene expression in eukaryotic cells. The Human Musashi-1 (MSI-1) is an RNA-binding protein that recognizes (G/A)U 1-3 AGU and UAG sequences in diverse RNAs through two RRMs and regulates the fate of target RNA. Here, we combined structural biology and computational approaches to analyse the binding of the RRM domains of human MSI-1 wi...

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Literature Corpus work: 20941bb5-8936-532d-9842-a815b59b999e
DOI: 10.1101/2024.10.24.619864

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