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Article

A conserved three-nucleotide core motif defines Musashi RNA binding specificity.

The Journal of biological chemistry - 19 Dec 2014

Zearfoss N Ruth, Deveau Laura M, Clingman Carina C, Schmidt Eric, Johnson Emily S, Massi Francesca, Ryder Sean P

Abstract excerpt

Musashi (MSI) family proteins control cell proliferation and differentiation in many biological systems. They are overexpressed in tumors of several origins, and their expression level correlates with poor prognosis. MSI proteins control gene expression by binding RNA and regulating its translation. They contain two RNA recognition motif (RRM) domains, which recognize a defined sequence element. The relative...

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Identifiers

PMID: 25368328
DOI: 10.1074/jbc.M114.597112
PMCID: PMC4271237

Genes

MSI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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