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Article

Destabilization of the human RED–SMU1 splicing complex as a basis for host-directed antiinfluenza strategy

10 May 2019

Abstract excerpt

New therapeutic strategies targeting influenza are actively sought due to limitations in current drugs available. Host-directed therapy is an emerging concept to target host functions involved in pathogen life cycles and/or pathogenesis, rather than pathogen components themselves. From this perspective, we focused on an essential host partner of influenza viruses, the RED-SMU1 splicing complex. Here, we...

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PMID: 31076555
DOI: 10.1073/pnas.1901214116

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