Article

Small molecule inhibition of multiple RNA binding proteins underlies Musashi-2 independent phenotypes

2022-09-20

Abstract excerpt

<h4>ABSTRACT</h4> RNA binding proteins (RBPs) are key regulators of gene expression. Small molecules targeting these RBP-RNA interactions are a rapidly emerging class of therapeutics for treating a variety of diseases. Ro-08-2750 (Ro) is a small molecule inhibitor identified as a competitive inhibitor of Musashi(MSI)-RNA interactions. Here we show Ro potently inhibits adrenocortical steroidogenesis and viability...

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Literature Corpus work: c3ebb6d7-d326-53c0-b3d0-f1960b813035
DOI: 10.1101/2022.09.20.508735

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