Article

Chronic intermittent hypoxia exposure induces a unique microglial transcriptome in 5XFAD mice

2025-04-21

Abstract excerpt

<title>Abstract</title> <p>Clinical observations suggest that obstructive sleep apnea (OSA) and Alzheimer’s disease (AD) pathology may be linked; however, causal mechanisms and relationships are unclear. To investigate the potential interaction between amyloidosis and intermittent hypoxia (IH), a hallmark of OSA, starting at 4-months of age 5XFAD mice were exposed to chronic IH (CIH) consisting of 20 episodes per...

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Literature Corpus work: 207f6772-313f-5cda-8eee-6711adfadf96
DOI: 10.21203/rs.3.rs-6203482/v1

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