Article
Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity.
Nature - 2 Oct 2014
Marusyk Andriy, Tabassum Doris P, Altrock Philipp M, Almendro Vanessa, Michor Franziska, Polyak Kornelia
Abstract excerpt
Cancers arise through a process of somatic evolution that can result in substantial sub-clonal heterogeneity within tumours. The mechanisms responsible for the coexistence of distinct sub-clones and the biological consequences of this coexistence remain poorly understood. Here we used a mouse xenograft model to investigate the impact of sub-clonal heterogeneity on tumour phenotypes and the competitive expansion...
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