Article

Mitochondrial RNA capping: highly efficient 5’-RNA capping with NAD <sup>+</sup> and NADH by yeast and human mitochondrial RNA polymerase

2018-07-31

Abstract excerpt

Bacterial and eukaryotic nuclear RNA polymerases (RNAPs) cap RNA with the oxidized and reduced forms of the metabolic effector nicotinamide adenine dinucleotide, NAD + and NADH, using NAD + and NADH as non-canonical initiating nucleotides for transcription initiation. Here, we show that mitochondrial RNAPs (mtRNAPs) cap RNA with NAD + and NADH, and do so more efficiently than nuclear RNAPs. Direct quantitation...

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Literature Corpus work: 205c82a1-ef41-54b1-9337-e3bd289e5221
DOI: 10.1101/381160

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