Article

Genetic Loss of Nicotinamide Nucleotide Transhydrogenase Prevents from Cardiometabolic Heart Failure with Preserved Ejection Fraction

2023-04-21

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Rationale</h4> Heart failure with preserved ejection fraction (HFpEF) represents a common clinical endpoint of cardiometabolic diseases which impair myocardial diastolic relaxation. Although myocardial redox perturbations are known to accompany HFpEF, the specific role of mitochondrial oxidative stress has not been demonstrated yet. <h4>Objective</h4> Based on an observation that C57BL6/N...

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Literature Corpus work: 0a05ffef-077a-578c-97af-09ef5785581d
DOI: 10.1101/2023.04.21.537792

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