Article

Natural Selection has Shaped Coding and Non-coding Transcription in Primate CD4+ T-cells

2016-10-25

Abstract excerpt

Transcriptional regulatory changes have been shown to contribute to phenotypic differences between species, but many questions remain about how gene expression evolves. Here we report the first comparative study of nascent transcription in primates. We used PRO-seq to map actively transcribing RNA polymerases in resting and activated CD4+ T-cells in multiple human, chimpanzee, and rhesus macaque individuals, with...

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Literature Corpus work: 2041d890-73b1-5048-9ed6-a7fbec408c90
DOI: 10.1101/083212

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