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Article

Impacts of Neanderthal-Introgressed Sequences on the Landscape of Human Gene Expression.

Cell - 23 Feb 2017

McCoy Rajiv C, Wakefield Jon, Akey Joshua M

Abstract excerpt

Regulatory variation influencing gene expression is a key contributor to phenotypic diversity, both within and between species. Unfortunately, RNA degrades too rapidly to be recovered from fossil remains, limiting functional genomic insights about our extinct hominin relatives. Many Neanderthal sequences survive in modern humans due to ancient hybridization, providing an opportunity to assess their contributions...

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Identifiers

PMID: 28235201
DOI: 10.1016/j.cell.2017.01.038
PMCID: PMC6219754

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