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Article

POLE mutations in endometrial carcinoma: Clinical and genomic landscape from a large prospective single‐center cohort

25 Jan 2025

Abstract excerpt

BACKGROUND: To date, 11 DNA polymerase epsilon (POLE) pathogenic variants have been declared "hotspot" mutations. Patients with endometrial cancer (EC) characterized by POLE hotspot mutations (POLEmut) have exceptional survival outcomes. Whereas international guidelines encourage deescalation of adjuvant treatment in early-stage POLEmut EC, data regarding safety in POLEmut patients with unfavorable...

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PMID: 39865420
DOI: 10.1002/cncr.35731

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