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Mutant POLQ and POLZ/REV3L DNA polymerases may contribute to favorable survival of tumors with POLE mutations outside the exonuclease domain

2020-02-03

Abstract excerpt

<title>Abstract</title> <p><bold>Purpose</bold>: Tumors with mutations in the exonuclease domain of POLE are associated with ultrahigh mutation rates. POLE mutant tumors are best characterized in intestinal and uterine cancers and are associated with a prominent immune infiltrate and favorable prognosis. To determine whether mutations in other DNA polymerases cooperate with POLE mutations to generate the ultramut...

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Literature Corpus work
7d1bc25b-fe47-588c-a06d-be77c338469d
DOI
10.21203/rs.2.22445/v1
Open publication

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Mutant POLQ and POLZ/REV3L DNA polymerases may contribute to favorable survival of tumors with POLE mutations outside the exonuclease domainDOI 10.21203/rs.2.22445/v1
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