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The game-changing impact of POLE mutations in oncology—a review from a gynecologic oncology perspective

22 Aug 2024

Abstract excerpt

Somatic mutations within the exonuclease proofreading domain (EDM) of the DNA polymerase Pol ϵ (POLE) gene are increasingly being discovered in ovarian, colorectal, urological, and, especially, endometrial carcinoma (EC), where these are found in up to 10% of the cases. In EC, there are five confirmed pathogenic somatic POLE-EDM mutations that are located at codons 286, 411, 297, 456, and 459, and these are...

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PMID: 39239272
DOI: 10.3389/fonc.2024.1369189

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