Article
Pathogenic POLE-Mutated Endometrial Carcinomas With a Nonultramutated Genome.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 2026
Srikumar Shruti, Evans Nick, Tjota Melissa Yuwono, Alikhan Mir, Kaur Amandeep, Sabatini Linda M, Miller Nick, Bouma Mike, Maniar Kruti P, Parilla Megan
Abstract excerpt
Endometrial carcinomas can be classified into 1 of 4 molecular subtypes, with the POLE-mutant subtype carrying the best prognosis. Pathogenic mutations in POLE are known to disrupt the proofreading function of DNA polymerase epsilon, resulting in an ultramutated genome, typically defined as ≥100 mutations per megabase. Routine next-generation sequencing was implemented on all endometrial carcinoma cases at our...
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