Distinct mutational landscape and clonal evolution of POLE-mutated endometrial cancer: geographic variation and insights into multiple classifier status.

Abstract excerpt

BACKGROUND: POLE-mutated (POLEmut) endometrial cancer (EC) represents a distinct molecular subtype with a favorable prognosis. However, current knowledge is derived largely from Western-centric datasets, and population-specific differences in mutational landscapes remain insufficiently explored. In addition, the biological relevance of variant type and the evolutionary dynamics of rare tumors with concurrent...

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