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Targeting the 3D genome by anthracyclines for chemotherapeutic effects

2024-10-17

Abstract excerpt

The chromatin is folded into three-dimensional (3D) structures, and aberrant 3D chromatin folding has been implicated in cancer. We performed ATAC-seq and TOP2A ChIP-seq to assess the potential effects of various anthracycline drugs on the chromatin architecture. We found that specific anthracycline variants selectively disrupt chromatin looping anchors by interfering with CTCF binding, suggesting an additional th...

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Identifiers and source

Literature Corpus work
202cb6a5-4559-5104-a6f7-4eef2a9c1742
DOI
10.1101/2024.10.15.614434
Open publication

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Targeting the 3D genome by anthracyclines for chemotherapeutic effectsDOI 10.1101/2024.10.15.614434
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