Article

AI4Loop: an Artificial Intelligence Framework Reveals Increased 3D Chromatin Interactions and Therapeutic Vulnerabilities across 12,000 Cancer Samples

2026-08-14

Abstract excerpt

Three-dimensional chromatin interactions shape gene regulation, but their large-scale analysis remains limited by the cost and complexity of experimental assays. Here we present AI4Loop, a deep learning framework that infers genome-wide gene-centered chromatin interaction networks directly from RNA-seq data. Across multiple cell types, AI4Loop recovered interaction patterns consistent with clinical samples and ort...

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Literature Corpus work: a97c2f4f-9e5e-521e-b1d8-d765cb130c65
DOI: 10.64898/2026.08.12.744314

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