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Chromatin as an old and new anticancer target

1 Jun 2024

Abstract excerpt

Recent genome-wide analyses identified chromatin modifiers as one of the most frequently mutated classes of genes across all cancers. However, chemotherapies developed for cancers involving DNA damage remain the standard of care for chromatin-deranged malignancies. In this review we address this conundrum by establishing the concept of 'chromatin damage': the non-genetic damage to protein-DNA interactions induced...

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PMID: 38825423
DOI: 10.1016/j.trecan.2024.05.005

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