Article
Interaction between host genes and M. tuberculosis lineage can affect tuberculosis severity: evidence for coevolution
2019-09-14
Abstract excerpt
Genetic studies of both the human host and Mycobacterium tuberculosis (MTB) demonstrate independent association with tuberculosis (TB) risk. However, neither explains a large portion of disease risk or severity. Based on studies in other infectious diseases and animal models of TB, we hypothesized that the genomes of the two interact to modulate risk of developing active TB or increasing the severity of disease,...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 202600a0-e9a6-516b-8fd3-8f2aa3f32f0b
- DOI
- 10.1101/769448