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Genome-wide host-pathogen analyses reveal genetic interaction points in tuberculosis disease

1 Feb 2023

Abstract excerpt

Abstract The genetics underlying tuberculosis (TB) pathophysiology are poorly understood. Human genome-wide association studies have failed so far to reveal reproducible susceptibility loci, attributed in part to the influence of the underlying Mycobacterium tuberculosis (Mtb) bacterial genotype on the outcome of the infection. Several studies have found associations of human genetic polymorphisms with Mtb...

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PMID: 36725857
DOI: 10.1038/s41467-023-36282-w

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