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Article

Interaction between host genes and Mycobacterium tuberculosis lineage can affect tuberculosis severity: Evidence for coevolution?

PLoS genetics - 1 Apr 2020

McHenry Michael L, Bartlett Jacquelaine, Igo Robert P, Wampande Eddie M, Benchek Penelope, Mayanja-Kizza Harriet, Fluegge Kyle, Hall Noemi B, Gagneux Sebastien, Tishkoff Sarah A, Wejse Christian, Sirugo Giorgio, Boom W Henry, Joloba Moses, Williams Scott M, Stein Catherine M

Abstract excerpt

Genetic studies of both the human host and Mycobacterium tuberculosis (MTB) demonstrate independent association with tuberculosis (TB) risk. However, neither explains a large portion of disease risk or severity. Based on studies in other infectious diseases and animal models of TB, we hypothesized that the genomes of the two interact to modulate risk of developing active TB or increasing the severity of disease,...

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Identifiers

PMID: 32352966
DOI: 10.1371/journal.pgen.1008728
PMCID: PMC7217476

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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