Human Genetic Variation Associates With Infection by Derived Ugandan M. tuberculosis Lineage.

doi:10.1093/infdis/jiag218

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Article

Human Genetic Variation Associates With Infection by Derived Ugandan M. tuberculosis Lineage.

The Journal of infectious diseases - 23 Sept 2026

Stein Catherine M, Benchek Penelope, Mantshoyane Lentlamatse, Ciesielski Timothy, McHenry Michael L, Wilson-Sesay Himiede, Joloba Moses, Wampande Eddie, Mc-Farland Kimberly A Dill, Roberts Allison W, Polacco Ben, Bennett Max, Krogan Nevan, Boom W Henry, Cox Jeffery S, Mayanja-Kizza Harriet, Hawn Thomas R, Williams Scott M

Abstract excerpt

BACKGROUND: Several studies have examined host and pathogen genetic influences on tuberculosis (TB) susceptibility separately, but relatively few studied their combined effects. However, host-pathogen interactions or co-evolution may explain the inability to replicate many reported human genetic effects across global populations and provide additional insight into TB risk. In this study, we address such possible...

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Topics

Humans
Uganda
Mycobacterium tuberculosis
Genetic Variation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Host-Pathogen Interactions

Genome-Wide Association Study

Tuberculosis

Female

Genetic Predisposition to Disease

Adult

Male

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 41999581
DOI: 10.1093/infdis/jiag218
PMCID: PMC13600372

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