Genome-to-genome analysis reveals associations between human and mycobacterial genetic variation in tuberculosis patients from Tanzania.

doi:10.1186/s12920-025-02164-x

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Article

Genome-to-genome analysis reveals associations between human and mycobacterial genetic variation in tuberculosis patients from Tanzania.

BMC medical genomics - 2 Jun 2025

Xu Zhi Ming, Zwyer Michaela, Hiza Hellen, Schmidiger Sarah, Sasamalo Mohamed, Reinhard Miriam, Doetsch Anna, Borrell Sonia, Naret Olivier, Rüeger Sina, Lawless Dylan, Tang Simon, Isihaka Faima, Temba Hosiana, Maroa Thomas, Naftari Rastard, Beisel Christian, Hella Jerry, Reither Klaus, Brites Daniela, Portevin Damien, Gagneux Sebastien, Fellay Jacques

Abstract excerpt

The risk and prognosis of tuberculosis (TB) are influenced by a complex interplay between human and bacterial genetic factors. While previous genomic studies have largely examined human and bacterial genomes separately, we adopted an integrated approach to uncover host-pathogen interactions. We leveraged paired human and Mycobacterium tuberculosis (M.tb) genomic data from 1000 adult TB patients from Tanzania and...

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Topics

Humans
Tanzania
Mycobacterium tuberculosis
Tuberculosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adult

Male

Female

Genetic Variation

Polymorphism, Single Nucleotide

Host-Pathogen Interactions

Genome, Bacterial

Genome-Wide Association Study

Genetic Predisposition to Disease

Middle Aged

Source

Open in PubMed Open full text

Identifiers

PMID: 40457403
DOI: 10.1186/s12920-025-02164-x
PMCID: PMC12131348

Genes

FBXO15
TIMM21
PRDM15

Variants

Provenance

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