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Article

Human genetic ancestry, Mycobacterium tuberculosis diversity, and tuberculosis disease severity in Dar es Salaam, Tanzania.

eLife - 24 Mar 2026

Zwyer Michaela, Xu Zhi Ming, Ross Amanda, Hella Jerry, Sasamalo Mohamed, Rotival Maxime, Hiza Hellen Charles, Rutaihwa Liliana K, Borrell Sonia, Reither Klaus, Fellay Jacques, Portevin Damien, Quintana-Murci Lluis, Gagneux Sebastien, Brites Daniela

Abstract excerpt

Infectious diseases have affected humanity for millennia and are among the strongest selective forces. Tuberculosis (TB) is an ancient disease, caused by the human-adapted members of the Mycobacterium tuberculosis complex (MTBC). The outcome of TB infection and disease is highly variable, and co-evolution between human populations and MTBC strains may account for some of this variability. Particular human genetic...

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Identifiers

PMID: 41875029
DOI: 10.7554/eLife.103533
PMCID: PMC13012724

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