Article
Conditional disruption of Axin1 leads to development of liver tumors in mice.
Gastroenterology - 1 Dec 2012
Feng Gui Jie, Cotta Welwyn, Wei Xiao Qing, Poetz Oliver, Evans Rebecca, Jardé Thierry, Reed Karen, Meniel Valerie, Williams Geraint T, Clarke Alan R, Dale Trevor C
Abstract excerpt
BACKGROUND & AIMS: Mutations in components of the Wnt signaling pathway, including β-catenin and AXIN1, are found in more than 50% of human hepatocellular carcinomas (HCCs). Disruption of Axin1 causes embryonic lethality in mice. We generated mice with conditional disruption of Axin1 to study its function specifically in adult liver. METHODS: Mice with a LoxP-flanked allele of Axin1 were generated by homologous...
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