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Article

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1.

Nature genetics - 1 Mar 2000

Satoh S, Daigo Y, Furukawa Y, Kato T, Miwa N, Nishiwaki T, Kawasoe T, Ishiguro H, Fujita M, Tokino T, Sasaki Y, Imaoka S, Murata M, Shimano T, Yamaoka Y, Nakamura Y

Abstract excerpt

The Wnt signaling pathway is essential for development and organogenesis. Wnt signaling stabilizes beta-catenin, which accumulates in the cytoplasm, binds to 1-cell factor (TCF; also known as lymphocyte enhancer-binding factor, LEF) and then upregulates downstream genes. Mutations in CTNNB1 (encoding beta-catenin) or APC (adenomatous polyposis coli) have been reported in human neoplasms including colon cancers...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10700176
DOI: 10.1038/73448

Genes

AXIN1
CTNNB1
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1.PMID 10700176Read ↗

Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas.Semantic proximity Read ↗

AXIN deficiency in human and mouse hepatocytes induces hepatocellular carcinoma in the absence of β-catenin activation.Semantic proximity Read ↗

Immunohistochemical analysis and mutational analyses of beta-catenin, Axin family and APC genes in hepatocellular carcinomas.Semantic proximity Read ↗

Unraveling the impact of AXIN1 mutations on HCC development: Insights from CRISPR/Cas9 repaired AXIN1-mutant liver cancer cell lines.Semantic proximity Read ↗

AXIN1 Mutated Hepatocellular Carcinoma.Semantic proximity Read ↗

Conditional disruption of Axin1 leads to development of liver tumors in mice.Semantic proximity Read ↗

Genetic alterations of Wnt signaling pathway–associated genes in hepatocellular carcinomaSemantic proximity Read ↗

Mutations of beta-catenin and AXIN I genes are a late event in human hepatocellular carcinogenesis.Semantic proximity Read ↗

Analysis of Tumor-Associated AXIN1 Missense Mutations Identifies Variants That Activate β-Catenin SignalingSemantic proximity Read ↗

Hepatocellular carcinoma-associated <i>AXIN1</i> mutations drive low levels of Wnt/β-catenin pathway activity that allow for niche-independent growth and YAP/TAZ signalingSemantic proximity Read ↗

Sequence variants of the axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding.Semantic proximity Read ↗

Tumor formation by genetic mutations in the components of the Wnt signaling pathway.Semantic proximity Read ↗

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