Article
Unraveling the impact of AXIN1 mutations on HCC development: Insights from CRISPR/Cas9 repaired AXIN1-mutant liver cancer cell lines.
PloS one - 1 Jan 2024
Zhang Ruyi, Li Shanshan, Schippers Kelly, Eimers Boaz, Niu Jiahui, Hornung Bastian V H, van den Hout Mirjam C G N, van Ijcken Wilfred F J, Peppelenbosch Maikel P, Smits Ron
Abstract excerpt
BACKGROUND: Hepatocellular carcinoma (HCC) is a highly aggressive liver cancer with significant morbidity and mortality rates. AXIN1 is one of the top-mutated genes in HCC, but the mechanism by which AXIN1 mutations contribute to HCC development remains unclear. METHODS: In this study, we utilized CRISPR/Cas9 genome editing to repair AXIN1-truncated mutations in five HCC cell lines. RESULTS: For each cell line we...
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