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Article

AXIN1 Mutated Hepatocellular Carcinoma.

The American journal of surgical pathology - 1 Jun 2026

Torbenson Michael, McCabe Chantal E, Hohenstein Jessica D, O'Brien Daniel, Chen Zongming E, Wu Tsung-Teh, Kakar Sanjay, Tran Nguyen H, Wang Chen

Abstract excerpt

CTNNB1- mutated hepatocellular carcinomas are characterized by a distinctive morphology and activation of the Wnt pathway. AXIN1 also plays a key role in the Wnt pathway, but the morphology of AXIN1-mutated tumors has not been examined. In addition, there are ongoing questions on the ability of AXIN1 mutations to activate the Wnt pathway in hepatocellular carcinoma. AXIN1 mutated tumors (N=18) were studied, along...

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Topics

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Share to Axin Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biomarkers, Tumor

Share to Carcinoma, Hepatocellular

Share to Glutamate-Ammonia Ligase

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Source

Identifiers

PMID: 41804058
DOI: 10.1097/PAS.0000000000002528

Genes

AXIN1
CTNNB1
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Research trail→

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AXIN1 Mutated Hepatocellular Carcinoma.PMID 41804058Read ↗

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Mutations of beta-catenin and AXIN I genes are a late event in human hepatocellular carcinogenesis.Semantic proximity Read ↗

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