Article

HDAC Inhibition Induces Patient-Specific Phenotypic Remodeling in Glioblastoma Organoids

2026-06-28

Abstract excerpt

<title>Abstract</title> <p>Glioblastoma (GBM) is the most aggressive primary brain tumor in adults and remains highly resistant to current therapies. Patient-derived glioblastoma organoids (gPDOs) preserve key histological and molecular features of the original tumors, providing clinically relevant models for investigating tumor biology and therapeutic vulnerabilities. Given the role of histone deacetylase (HDAC)...

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Literature Corpus work: 1fa5b128-c84b-51fc-924b-41c92ea5e074
DOI: 10.21203/rs.3.rs-10071781/v1

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