Article

Targeting Glioblastoma Cell State Plasticity for Enhanced Therapeutic Efficacy

2025-09-12

Abstract excerpt

<h4>Summary</h4> Glioblastoma (GBM) is the most common and deadly primary brain cancer, with limited therapeutic options. Treatment failure has been associated with intratumoral heterogeneity and the acquisition of a pronounced mesenchymal-like (MES-L) phenotype after recurrence. Here, we have screened a panel of drugs with diverse mechanisms of action across two patient-derived glioblastoma stem cells (GSCs) to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1877d2c3-922e-54d2-952e-ddba39a43ebf
DOI: 10.1101/2025.09.08.674897

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting Glioblastoma Cell State Plasticity for Enhanced Therapeutic EfficacyDOI 10.1101/2025.09.08.674897Read

Multi-omics and Pharmacological Characterization of Patient-derived Glioma Cell LinesSemantic proximity Read

Microenvironment-Driven Dynamic Chromatin Changes in Glioblastoma Recapitulate Early Neural Development at Single-Cell ResolutionSemantic proximity Read

A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade gliomaSemantic proximity Read

Multi-omics and pharmacological characterization of patient-derived glioma cell linesSemantic proximity Read

The functional genomic circuitry of human glioblastoma stem cellsSemantic proximity Read

Network Analyses of Brain Tumor Patients’ Multiomic Data Reveals Pharmacological Opportunities to Alter Cell State TransitionsSemantic proximity Read

Neuronal and tumourigenic boundaries of glioblastoma plasticitySemantic proximity Read

Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal TransitionSemantic proximity Read

Gene regulatory network topology governs resistance and treatment escape in glioma stem-like cellsSemantic proximity Read

Fitness Screens Map State-Specific Glioblastoma Stem Cell VulnerabilitiesSemantic proximity Read

Gene regulatory network topology governs resistance and treatment escape in glioma stem-like cellsSemantic proximity Read

HDAC Inhibition Induces Patient-Specific Phenotypic Remodeling in Glioblastoma OrganoidsSemantic proximity Read