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Nonredundant, isoform-specific roles of HDAC1 in glioma stem cells.

JCI insight - 8 Sept 2021

Lo Cascio Costanza, McNamara James B, Melendez Ernesto L, Lewis Erika M, Dufault Matthew E, Sanai Nader, Plaisier Christopher L, Mehta Shwetal

Abstract excerpt

Glioblastoma (GBM) is characterized by an aberrant yet druggable epigenetic landscape. One major family of epigenetic regulators, the histone deacetylases (HDACs), are considered promising therapeutic targets for GBM due to their repressive influences on transcription. Although HDACs share redundant functions and common substrates, the unique isoform-specific roles of different HDACs in GBM remain unclear. In...

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Histone Deacetylase 1
Neoplastic Stem Cells
Protein Isoforms
Apoptosis
DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Profiling

Tumor Cells, Cultured

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Identifiers

PMID: 34494550
DOI: 10.1172/jci.insight.149232
PMCID: PMC8492336

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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