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Article

Histone deacetylase inhibitors exert anti-tumor effects on human adherent and stem-like glioma cells

17 Jan 2019

Abstract excerpt

BACKGROUND: The diagnosis of glioblastoma (GBM), a most aggressive primary brain tumor with a median survival of 14.6 months, carries a dismal prognosis. GBMs are characterized by numerous genetic and epigenetic alterations, affecting patient survival and treatment response. Epigenetic mechanisms are deregulated in GBM as a result of aberrant expression/activity of epigenetic enzymes, including histone...

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Share to Epigenetics and DNA Methylation
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PMID: 30654849
DOI: 10.1186/s13148-018-0598-5

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