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Article

Epigenetic regulation in medulloblastoma pathogenesis revealed by genetically engineered mouse models.

Cancer science - 1 Aug 2021

Shiraishi Ryo, Kawauchi Daisuke

Abstract excerpt

Medulloblastoma is the most common malignant cerebellar tumor in children. Recent technological advances in multilayered 'omics data analysis have revealed 4 molecular subgroups of medulloblastoma (Wingless/int, Sonic hedgehog, Group3, and Group4). (Epi)genomic and transcriptomic profiling on human primary medulloblastomas has shown distinct oncogenic drivers and cellular origin(s) across the subgroups. Despite...

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Identifiers

PMID: 34050694
DOI: 10.1111/cas.14990
PMCID: PMC8353939

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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