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Article

Genetic drivers of metastatic dissemination in sonic hedgehog medulloblastoma.

Acta neuropathologica communications - 25 Jul 2014

Jenkins Noah C, Kalra Ricky R, Dubuc Adrian, Sivakumar Walavan, Pedone Carolyn A, Wu Xiaochong, Taylor Michael D, Fults Daniel W

Abstract excerpt

Leptomeningeal dissemination (LMD), the metastatic spread of tumor cells via the cerebrospinal fluid to the brain and spinal cord, is an ominous prognostic sign for patients with the pediatric brain tumor medulloblastoma. The need to reduce the risk of LMD has driven the development of aggressive treatment regimens, which cause disabling neurotoxic side effects in long-term survivors. Transposon-mediated...

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Source

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Identifiers

PMID: 25059231
DOI: 10.1186/s40478-014-0085-y
PMCID: PMC4149244

Genes

SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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