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Engineering TadA ortholog-derived cytosine base editor without motif preference and adenosine activity limitation

16 Sept 2024

Abstract excerpt

The engineered TadA variants used in cytosine base editors (CBEs) present distinctive advantages, including a smaller size and fewer off-target effects compared to cytosine base editors that rely on natural deaminases. However, the current TadA variants demonstrate a preference for base editing in DNA with specific motif sequences and possess dual deaminase activity, acting on both cytosine and adenosine in...

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PMID: 39284833
DOI: 10.1038/s41467-024-52485-1

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