Article
Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus.
Molecular medicine (Cambridge, Mass.) - 1 Jan 2000
Lee Hye-Soon, Lee Annette T, Criswell Lindsey A, Seldin Michael F, Amos Christopher I, Carulli John P, Navarrete Cristina, Remmers Elaine F, Kastner Daniel L, Plenge Robert M, Li Wentian, Gregersen Peter K
Abstract excerpt
Recent evidence suggests that additional risk loci for RA are present in the major histocompatibility complex (MHC), independent of the class II HLA-DRB1 locus. We have now tested a total of 1,769 SNPs across 7.5Mb of the MHC located from 6p22.2 (26.03 Mb) to 6p21.32 (33.59 Mb) derived from the Illumina 550K Beadchip (Illumina, San Diego, CA, USA). For an initial analysis in the whole dataset (869 RA CCP + cases,...
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