Article
Influence of HLA Class II Alleles and DRB1-DQB1 Haplotypes on Rheumatoid Arthritis Susceptibility and Autoantibody Status in the Chinese Han Population.
Immunological investigations - 1 Jul 2022
Wan Xin, Wang Ying, Jin Peipei, Zhang Ju, Liu Liu, Wang Zhangfei, Hu Yue
Abstract excerpt
Human leukocyte antigen (HLA) class II alleles are considered to play a key role in the progress of rheumatoid arthritis (RA). This study was carried out to investigate the presence of HLA class II alleles and their influence on disease risk and autoantibody status in Chinese Han patients with RA. Here, HLA-DRB1, DQB1 and DPB1 genotyping was performed in 125 RA patients and 120 healthy controls by using the...
Topics
- Alleles
- Anti-Citrullinated Protein Antibodies
- Arthritis, Rheumatoid
- Autoantibodies
- China
- Gene Frequency
- Genetic Predisposition to Disease
- HLA-DP beta-Chains
- HLA-DQ beta-Chains
- HLA-DRB1 Chains
- Haplotypes
- Humans
- Risk