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Article

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose.

Cell metabolism - 13 Sept 2016

Johnston Natalie R, Mitchell Ryan K, Haythorne Elizabeth, Pessoa Maria Paiva, Semplici Francesca, Ferrer Jorge, Piemonti Lorenzo, Marchetti Piero, Bugliani Marco, Bosco Domenico, Berishvili Ekaterine, Duncanson Philip, Watkinson Michael, Broichhagen Johannes, Trauner Dirk, Rutter Guy A, Hodson David J

Abstract excerpt

The arrangement of β cells within islets of Langerhans is critical for insulin release through the generation of rhythmic activity. A privileged role for individual β cells in orchestrating these responses has long been suspected, but not directly demonstrated. We show here that the β cell population in situ is operationally heterogeneous. Mapping of islet functional architecture revealed the presence of hub...

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Identifiers

PMID: 27452146
DOI: 10.1016/j.cmet.2016.06.020
PMCID: PMC5031557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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