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Article

Novel regulators of islet function identified from genetic variation in mouse islet Ca2+ oscillations.

eLife - 3 Oct 2023

Emfinger Christopher H, Clark Lauren E, Yandell Brian, Schueler Kathryn L, Simonett Shane P, Stapleton Donnie S, Mitok Kelly A, Merrins Matthew J, Keller Mark P, Attie Alan D

Abstract excerpt

Insufficient insulin secretion to meet metabolic demand results in diabetes. The intracellular flux of Ca2+ into β-cells triggers insulin release. Since genetics strongly influences variation in islet secretory responses, we surveyed islet Ca2+ dynamics in eight genetically diverse mouse strains. We found high strain variation in response to four conditions: (1) 8 mM glucose; (2) 8 mM glucose plus amino acids;...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37787501
DOI: 10.7554/eLife.88189
PMCID: PMC10547476

Genes

ABCC8
GCK
GIP
PCSK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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