Article
Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice.
Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 2010
Colsoul Barbara, Schraenen Anica, Lemaire Katleen, Quintens Roel, Van Lommel Leentje, Segal Andrei, Owsianik Grzegorz, Talavera Karel, Voets Thomas, Margolskee Robert F, Kokrashvili Zaza, Gilon Patrick, Nilius Bernd, Schuit Frans C, Vennekens Rudi
Abstract excerpt
Glucose homeostasis is critically dependent on insulin release from pancreatic beta-cells, which is strictly regulated by glucose-induced oscillations in membrane potential (V(m)) and the cytosolic calcium level ([Ca(2+)](cyt)). We propose that TRPM5, a Ca(2+)-activated monovalent cation channel, is a positive regulator of glucose-induced insulin release. Immunofluorescence revealed expression of TRPM5 in...
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